COMEDOGENICITY OF SQUALENE MONOHYDROPEROXIDE IN THE SKIN AFTER TOPICAL APPLICATION
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概要
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The comedogenicity of squalene peroxides was examined on the rabbit ear skin after topical application of squalene-monohydroperoxide (Sq-OOH), the initial product when squalene was irradiated with UV-A. Since comedogenic products from UV-irradiated squalene were extracted with methanol solution, we isolated Sq-OOH by reverse-phased HPLC with a methanol mobile phase solvent. The degree of comedogehnic reaction induced by Sq-OOH was higher than that of well-known comedogenic cosmetic ingredients. Unlike two other mono-peroxides, tert-butyl hydroperoxide and cumene-mono-hydroperoxide, Sq-OOH induced comedo-formation in the rabbit ear skin. However, the comedogenicity of reduced SqOOH, squalene-hydroxide (Sq-OH) and squalene itself was lower than that of Sq-OOH. These results indicate that Sq-OOH is a potent comedogenic mono-hydroperoxide chemical to rabbit skin.
- 日本トキシコロジー学会の論文
- 2000-05-11
著者
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Chiba Katsuyoshi
第一製薬
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Chiba Katsuyoshi
Department Of Toxicology Safety Research Center Yakult Central Institute For Microbiological Researc
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Chiba Katsuyoshi
Department Of Toxicology Safety Research Center Yakult Central Lnstitute For Microbiological Researc
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ONOUE Masaharu
Department of Toxicology, Safety Research Center, Yakult Central Institute for Microbiological Resea
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Onoue Masaharu
ヤクルト中央研究所
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Onoue Masaharu
Yakult Central Inst. For Microbiological Res.
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KAWAKAMI Koji
Yakult Central Institute for Microbiological Research
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YOSHIZAWA Kazuhiko
Department of Toxicology, Safety Research Center, Yakult Central lnstitute for Microbiological Resea
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MAKINO Ikuyo
Department of Toxicology, Safety Research Center, Yakult Central lnstitute for Microbiological Resea
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KAWAKAMI Koji
Department of Toxicology, Safety Research Center, Yakult Central lnstitute for Microbiological Resea
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Yoshizawa Kazuhiko
Department Of Toxicology Safety Research Center Yakult Central Lnstitute For Microbiological Researc
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Yoshizawa Kazuhiko
ヤクルト
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Yoshizawa Kazuhiko
Department Of Toxicology Safety Research Center Yakult Central Institute For Microbiological Researc
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Makino Ikuyo
Yakult Central Inst. For Microbiological Res.
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Makino Ikuyo
ヤクルト
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Kawakami Koji
Yakult Central Inst. Microbiological Res. Tokyo Jpn
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Makino Ikuyo
Department Of Toxicology Safety Research Center Yakult Central Lnstitute For Microbiological Researc
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Onoue Masaharu
Department Of Toxicology Safety Research Center Yakult Central Lnstitute For Microbiological Researc
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Kawakami Koji
Department Of Otorhinolaryngology Yokohama City University School Of Medicine
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Onoue M
Central Institute For Microbiological Research
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