The Effects of a Synbiotic Fermented Milk Beverage Containing Lactobacillus casei Strain Shirota and Transgalactosylated Oligosaccharides on Defecation Frequency, Intestinal Microflora, Organic Acid Concentrations, and Putrefactive Metabolites of Sub-Opti

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概要

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• We evaluated the effects of ingestion of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota (LcS) at 3 × 1010 and transgalactosylated oligosaccharides (GOS) at 2.5 g per 80 ml (once a day, 2 weeks) on the defecation frequency in 35 female university students with constipation as well as the defecation frequency, intestinal microflora, and intestinal environment in elderly persons in whom the intestinal microflora and the levels of putrefactive metabolites were abnormal in a placebo-controlled double-blind study. In the female students, the defecation frequency after 1 week of synbiotic fermented milk beverage ingestion was significantly higher than that after 1 week of placebo ingestion or before ingestion. In the elderly persons, the fecal Bifidobacterium and Lactobacillus bacterial counts after 1 and 2 weeks of synbiotic fermented milk beverage ingestion were significantly higher than those after placebo ingestion or before ingestion (p<0.05 and p<0.01, respectively). The fecal lecithinase-positive Clostridium bacterial count after 1 week of synbiotic fermented milk beverage ingestion and the fecal Enterobacteriaceae bacterial counts after 1 and 2 weeks of synbiotic fermented milk beverage ingestion were significantly lower than those after placebo ingestion (p<0.05). LcS at 107 CFU per gram of stool was collected during the ingestion period. The acetic acid levels after 1 and 2 weeks of synbiotic fermented milk beverage ingestion were significantly higher than those after placebo ingestion (p<0.01). The stool pH values after 1 and 2 weeks of synbiotic fermented milk beverage ingestion and the ammonia and phenol levels after 2 weeks of synbiotic fermented milk beverage ingestion were significantly lower than those after placebo ingestion (p<0.05). These results suggest that ingestion of the synbiotic fermented milk beverage containing LcS and GOS improves the stool quality, intestinal microflora, and intestinal environment.

• 日本ビフィズス菌センターの論文
• 2006-10-01

著者

• Asahara Takashi

  Yakult Central Institute for Microbiological Research

• KAWAKAMI Koji

  Yakult Central Institute for Microbiological Research

• Nomoto Koji

  Yakult Central Institute for Microbiological Research

• Nomoto Koji

  ヤクルト中央研究所

• Kawakami Koji

  Yakult Central Inst. Microbiological Res. Tokyo Jpn

• SHIOIRI Terue

  Tokyo Kasei University

• YAHAGI Keiko

  Tokyo Kasei University

• NAKAYAMA Sachie

  Tokyo Kasei University

• YUKI Norikatsu

  Yakult Central Institute for Microbiological Research

• YAMAOKA Yoshitaku

  Yakult Honsha Co., Ltd.

• SAKAI Yuko

  Yakult Honsha Co., Ltd.

• TOTANI Masumi

  Tokyo Kasei University

• Sakai Yuko

  Yakult Honsha Co. Ltd.

• Yahagi Keiko

  Tokyo Kasei Univ. Tokyo Jpn

• Asahara Takashi

  Yakult Central Inst. For Microbiological Res.

• Yamaoka Yoshitaku

  Yakult Honsha Co. Ltd.

• Nomoto Koji

  Yakult Central Inst. For Microbiological Res. Tokyo Jpn

• YAMAOKA Yoshitaku

  Yakult Honsha Co. Ltd

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