Acceleration of Granulocytic Cell Recovery in Irradiated Mice by a Single Subcutaneous Injection of a Heat-Killed Lactobacillus casei Preparation
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概要
- 論文の詳細を見る
Flow cytometric analysis showed that the treatment of irradiated mice with a heat-killed Lactobacillus casei preparation (LC 9018) accelerated the recovery of granulocytic cell populations in peripheral blood, spleen and femur bone marrow. The recovery of the lymphocytic cell population was not accelerated while the recovery of the B-lymphocytic cell population was inhibited. Histological analysis also showed that the LC-9018 treatment markedly enhanced granulopoiesis in the spleen and bone marrow of irradiated mice. The same LC-9018 treatment significantly increased 30-day survival rates of athymic nude mice after lethal whole-body irradiation. The recovery of the granulocytic cell population in peripheral blood of irradiated athymic nude mice was also accelerated by LC-9018 treatment. Our results suggest that LC 9018 protected lethally irradiated mice from bone marrow death by enhancing granulopuiesis rather than lymphopoiesis and that the contribution of activated T lymphocytes to the enhancement of the granulopoiesis was small.
- 日本放射線影響学会の論文
著者
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Nomoto Koji
Yakult Central Institute for Microbiological Research
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Uchida Kazumi
Yakult Central Institute For Microbiological Research
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Furuse Masako
放射線医学総合研究所
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Furuse Masako
Bioregulation Research Group National Institute Of Radiological Sciences
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TSUNEOKA Kazuko
Bioregul. Res. Group, Natl. Insti. Radiol. Sci.
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Tsuneoka K
Bioregulation Research Group National Institute Of Radiological Sciences
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Nomoto K
Yakult Central Inst. Microbiological Res. Tokyo Jpn
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Nomoto Koji
Yakult Central Inst. For Microbiological Res. Tokyo Jpn
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