Plasma Bradykinin and Prostaglandin Metabolism and Exercise Testing in Patients with Silent Myocardial Ischemia Compared with Patients with Painful Myocardial Ischemia : PANEL DISCUSSION ON SILENT MYOCARDIAL ISCHEMIA
スポンサーリンク
概要
- 論文の詳細を見る
Bradykinin, alone or in combination with prostaglandin, is thought to produce pain in patients with coronary heart disease. To elucidate this further, we have investigated and compared serum bradykinin, TXB_2 and 6KPGF_<1α> levels in patients with silent myocardial ischemia (SMI, n=18), painful myocardial ischemia (PMI,n=8) and normal subjects (NL, n=18). In addition, SMI and PMI subjects were given exercise testing and the results then compared. After Holter monitoring for 48 hours, exercise testing was performed. Blood was sampled in the morning between the Holter and exercise regimen. Maximal heart rate, systolic blood pressure and the double products were not significantly different between the SMI and PMI groups. The duration of exercise for the SMI group was 7.08±2.1 min vs 5.9±1.9 in the PMI group (p<0.10). Plasma bradykinin was 14±3 pg/ml in the SMI group and 15±3 in the PMI group (N.S), whereas it was 7±4 in the NL (p<0.05). The TXB_2/6KPGF_<1α> for the SMI group was 1.3±0.3, which was significantly higher than that for the NL group (0.8±0.3, p<0.01), though this did not greatly differ from the PMI group (1.2±0.3). These results suggest that SMI patients under Holter monitoring who manifest no symptoms but show significant ST segment depressions must receive the same careful attention given to PMI patients. In both group of patients bradykinin and prostaglandin metabolism is similarly change, as was demonstrated by exercise stress testing.
- 社団法人日本循環器学会の論文
- 1989-11-20
著者
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MIZUNO Kyoichi
Department of Internal Medicine, Nippon Medical School
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Mizun Kyoichi
Department Of Medical Engineering National Defense Medical College Graduate School
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Nakamura Haruo
Department of Cardiovascular Surgery, Toranomon Hospital
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Nakamura Haruo
Mitsukoshi Health And Welfare Foundation
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Nishioka Toshihiko
Division Of Cardiology Saitama Medical Center
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Nishioka Toshihiko
Saitama Medical Center Saitama Medical School Division Of Cardiology
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Uehata Akimi
Department of Internal Medicine, Japan Self Defense Froce Sendai Hospital
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Takase Bonpei
Department of Cardiovascular Medicine, National Defense Medical College
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Satomura Kimio
Department of Cardiovascular Medicine, National Defense Medical College
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Nagayoshi Hirokazu
National Defense Medical College
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KURITA AKIRA
Department of Internal Medicine, National Defense Medical College
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MARUYAMA TOSHIHARU
Department of Internal Medicine, National Defense Medical College
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NISHIOKA TOSHIO
Department of Internal Medicine, National Defense Medical College
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SUGAWARA HIROKO
Department of Internal Medicine, National Defense Medical College
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NAGAYOSHI HIROKAZU
Department of Internal Medicine, National Defense Medical College
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Maruyama Toshiaki
National Defense Medical College
-
Sugahara Hiroko
National Defense Medical College
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Satomura Kimio
Internal Medicine I National Defense Medical College
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Mizun Kyoichi
Cedars-sinai Medical Center And National Defense Medical College
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Uehata Akimi
Self Defense Forces Central Hospital, Internal Medicine
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Kurita Akira
Department Of Internal Medicine Nippon Medical School
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Mizuno Kyoichi
Department Of 1st Internal Medicine Nippon Medical School
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Nakamura Haruo
Department Of Cardiovascular Surgery Toranomon Hospital
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Nakamura Haruo
First Department Of Internal Medicine National Defence Medical Collage
-
Satomura Kimio
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
-
Kikuchi Makoto
Department Of Medical Engineering National Defense Medical College Graduate School
-
Mizuno Kyoichi
Department Of Emergency
-
Satomura Kirnio
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
-
Kurita Akira
Department Of Information Science Fukui University
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Sugahara Hiroko
Department Of Internal Medicine National Defense Medical College
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Kurita Akira
Department Of Cardiology Nippon Medical School
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Satomura Kimio
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
-
Maruyama Toshiharu
The 1st Department Of Internal Medicine National Defense Medical College
-
Uehata Akimi
Department Of Cardiology Self Defense Central Hospital
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