EFFICACY OF CARBON MONOXIDE LASER IN SELECTIVELY INTIMAL THERMAL WELDING : Implications for Laser Balloon Angioplasty

概要

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Excessive vascular damage causes excessive vascular repair, which results in re-stenosis. To limit the thickness of the coagulation layer in laser balloon angioplasty, we used a carbon monoxide (CO) laser, which has high tissue absorption, as a therapy laser source instead of a Nd: YAG laser. To investigate the benefit of short-penetration CO laser light to vascular tissue, excised human abdominal aorta was irradiated with a CO laser through a 30μm polyethylene membrane. The temperature of the vascular tissue was continuously monitored during irradiation. CO laser irradiation of 20 W/cm^2 was performed in either a continuous mode or an intermittent mode with various duty ratios (exposure/interval duration). With a total fluence of 200 J/cm^2, the adventitial temperature decreased as the duty ratio was reduced. The adventitial temperature at a duty ratio of 1 : 2 was 43℃. Microscopic examination of aorta which had been intermittently irradiated duty ratio of 1 : 2 showed thermal coagulation localized within the intima and a flattened intimal surface. These results suggest that intermittent laser irradiation with a CO laser can be used to limit the depth of thermal coagulation, and can selectively weld the intima without excessive thermal damage. Laser balloon angioplasty using a CO laser may help to prevent restenosis.
社団法人日本循環器学会の論文
1993-07-20