Plasma Matrix Metalloproteinase-8 Concentrations are Associated With the Presence and Severity of Coronary Artery Disease

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概要

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• Background Interstitial collagen, especially type I, is a major component of atherosclerotic plaques and the matrix metalloproteinases (MMP) 1, 8 and 13 can initiate collagen breakdown. MMP-8 degrades type I collagen preferentially and more potently than MMP-1 or MMP-13. Although MMP-8 was thought to be produced only by neutrophils, it was recently reported to also be produced by endothelial cells, smooth muscle cells and macrophages in plaques. Methods and Results Plasma MMP-8 concentrations were measured in 250 patients undergoing coronary angiography for coronary artery disease (CAD : >50% stenosis), which was found in 181 patients, of whom 69 had 1-vessel, 66 had 2-vessel, and 46 had 3-vessel disease. Compared with 69 patients without CAD, the 181 with CAD had higher MMP-8 concentrations (3.5 vs 3.0ng/ml, p<0.001). There was a stepwise increase in MMP-8 concentration depending on the number of stenotic vessels : 3.2 in 1-vessel, 3.6 in 2-vessel, and 4.3ng/ml in 3-vessel disease (p<0.001). Multivariate analysis showed that MMP-8 concentration was independently associated with CAD. The odds ratio for CAD was 1.22 (95%confidence interval=1.07-1.39) for a 1ng/ml increase in MMP-8 concentration. Conclusions Plasma MMP-8 concentration is associated with the presence and severity of CAD.

• 社団法人日本循環器学会の論文
• 2005-08-20

著者

• Nakamura Haruo

  National Defense Medical College

• Nakamura Haruo

  Mitsukoshi Health And Welfare Foundation

• Ohsuzu Fumitaka

  First Department of Internal Medicine, National Defense Medical College

• Momiyama Yukihiko

  National Defense Medical College

• Ohmori Reiko

  National Defense Medical College

• Taniguchi Hiroaki

  National Defense Medical College

• Momiyama Yukihiko

  First Department of Internal Medicine, National Defence Medical College,Saitama

• Kato Ryuichi

  National Defense Medical College

• Ohmori Reiko

  First Department Of Internal Medicine National Defense Medical College

• Taniguchi Hiroaki

  First Department of Internal Medicine, National Defense Medical College

• Ohsuzu Fumitaka

  Department Of Internal Medicine National Defense Medical College

• Osuzu Fumitaka

  First Department Of Internal Medicine National Defence Medical Collage

• Kato Ryuichi

  First Department of Internal Medicine, National Defense Medical College

• Nakamura H

  National Defense Medical College

• Momiyama Yukihiko

  Division Of Cardiology National Hospital Organization Tokyo Medical Center

• Momiyama Yukihiko

  First Department Of Internal Medicine National Defence Medical College

• Momiyama Yukihiko

  First Department Of Internal Medicine National Defence Medical College Saitama

• Ohsuzu Fumitaka

  First Department Of Internal Medicine National Defence Medical Collage

• Katoh Ryuichi

  First Department Of Internal Medicine National Defense Medical College

• Nakamura Haruo

  1st Department Of Medicine National Defense Medical College

• Ohsuzu Fumitaka

  First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C

• Nakamura Haruo

  1st Department Of Internal Medicine National Defense Medical College

• Nakamura Haruo

  First Department Of Internal Medicine National Defence Medical Collage

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