Rapid Progression of Cardiomyopathy in Mitochondrial Diabetes

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概要

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• Cardiac involvement and its clinical course in a diabetic patient with a mitochondrial tRNA^<Leu(UUR)> mutation at position 3243 is reported in a 54-year-old man with no history of hypertension. At age 46, an electrocardiogram showed just T wave abnormalities. At age 49, it fulfilled SV_1 + RV_<5 or 6> >35 mm with strain pattern. At age 52, echocardiography revealed definite left ventricular(LV) hypertrophy, and abnormally increased mitochondria were shown in biopsied endomyocardial specimens. He was diagnosed as having developed hypertrophic cardiomyopathy associated with the mutation. However, at age 54, SV_1 and RV_<5, 6> voltages were decreased, and echocardiography showed diffuse decreased LV wall motion and LV dilatation. Because he had mitochondrial diabetes, the patient's heart rapidly developed hypertrophic cardiomyopathy, and then it seemed to be changing to a dilated LV with systolic dysfunction. Rapid progression of cardiomyopathy can occur in mitochondrial diabetes.

• 社団法人日本循環器学会の論文
• 1999-01-20

著者

• OHSUZU Fumitaka

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Ohsuzu Fumitaka

  First Department of Internal Medicine, National Defense Medical College

• Kimura Mitsuru

  Tokyo Women's Medical University

• Ohsuzu Fumitaka

  Department Of Internal Medicine 1^<st> National Defense Medical College

• KIMURA MITSURU

  Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine

• Momiyama Yukihiko

  Divisions of Internal Medicine Tokyo Saiseikai Central Hospital

• Atsumi Yoshihito

  Divisions of Internal Medicine Tokyo Saiseikai Central Hospital

• Ui Susumu

  Divisions of Internal Medicine Tokyo Saiseikai Central Hospital

• Morinaga Shojirou

  Pathology, Tokyo Saiseikai Central Hospital

• Matsuoka Kempei

  Divisions of Internal Medicine Tokyo Saiseikai Central Hospital

• Momiyama Yukihiko

  Division Of Cardiology National Hospital Organization Tokyo Medical Center

• Momiyama Yukihiko

  First Department Of Internal Medicine National Defense Medical College

• Kamisago Mitsuhiro

  Tokyo Women's Medical University

• Kimura Mitsuru

  Division Of Clinical Research National Institute On Alcoholism Kurihama National Hospital

• Morinaga Shojirou

  Pathology Tokyo Saiseikai Central Hospital

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