Soluble Elastin Decreases in the Progress of Atheroma Formation in Human Aorta
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概要
- 論文の詳細を見る
Background: The serum levels of soluble elastin increase in patients with aortic dissection, but its distribution and characteristics are unclear. Methods and Results: The 173 aortic specimens were categorized into 4 groups under microscopy (non-atherosclerotic aorta, n=13; fiber-rich plaque, n=77; lipid-rich plaque, n=66; ruptured plaque, n=17). Soluble elastin was abundant within the intima of both the non-atherosclerotic aorta and fiber-rich plaque, rather than in the media, and was decreased within the intima of lipid-rich and ruptured plaques. Soluble elastin levels decreased with progress of atherosclerosis (6.0 ±0.3 μg/mg protein in non-atherosclerotic aorta; 5.8 ±0.2 μg/mg protein in fiber-rich plaque; 4.9 ±0.2 μg/mg protein in lipid-rich plaque; 2.8 ±0.4 μg/mg protein in ruptured plaque, P<0.05). As well, both matrix metalloprotease-9 activity and elastin mRNA expression showed inverse distribution against soluble elastin (r=0.437, P<0.0001; r=0.186, P<0.05, respectively). Multivariable analysis revealed a decrease in the level of soluble elastin in ruptured plaque (2.8 ±0.4 μg/mg protein in ruptured plaque, n=18; 5.5 ±0.2 μg/mg protein in non-ruptured plaque, n=155, P<0.01). Furthermore, western blot showed soluble elastin consists of heterogeneous molecular pattern proteins. Conclusions: Both the synthesis and degradation of elastin may be enhanced in active atherosclerotic lesions.
- 社団法人 日本循環器学会の論文
- 2009-10-20
著者
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SUZUKI Kimihiro
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College
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OHSUZU Fumitaka
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College
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Akima Takashi
Department of Cardiovascular Medicine, National Defense Medical College
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Suzuki Kimihiro
Department Of Internal Medicine Division Of Rheumatology National Defense Medical College
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Suzuki Kimihiro
Department Of Internal Medicine National Defense Medical College
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Kihara Teruyoshi
Iruma Heart Hospital
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NAKANISHI Kuniaki
Department of Pathology and Laboratory Medicine, National Defense Medical College
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KATAYAMA Masahiko
Diagnostic Department, Tsukuba Research Laboratories, Eisai Co Ltd
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KAWAI Toshiaki
Department of Pathology and Laboratory Medicine, National Defense Medical College
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Ohsuzu Fumitaka
Department Of Internal Medicine National Defense Medical College
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Osuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Ohsuzu Fumitaka
Department Of Internal Medicine 1^<st> National Defense Medical College
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Akima Takashi
Department Of Pathology And Laboratory Medicine National Defense Medical College
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Katayama Masahiko
Diagnostic Department Tsukuba Research Laboratories Eisai Co Ltd
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Nakanishi Kuniaki
Department Of Pathology And Laboratory Medicine National Defense Medical College
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Ohsuzu Fumitaka
Department Of Medicine 1 Division Of Cardiology National Defense Medical College
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Kawai Toshiaki
Department Of Pathology And Laboratory Medicine National Defense Medical College
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Ohsuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Ohsuzu Fumitaka
1st Department Of Medicine National Defense Medical College
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Ohsuzu Fumitaka
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
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Akima Takashi
First Department Of Internal Medicine National Defense Medical College
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Ohsuzu Fumitaka
National Defense Medical College Department Of Internal Medicine-i
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Nakanishi Kuniaki
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of Medicine
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Ohsuzu Fumitaka
National Defense Medical College Internal Medicine-1
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