Negative Correlation of Anti-U1RNP Antibody Titers and the Amount of Salivary Secretion with Age Correction
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概要
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Objective The aim of this study was to reveal whether or not the presence of anti-U1RNP antibodies is associated with a low amount of salivary secretion (ASS). Subjects and Methods Twenty females (mean age 49±12 years) who had anti-U1RNP but not ACA, anti-Ro, or anti-La antibodies (anti-U1RNP-positive group), and 65 control females (mean age 50±12 years) were included in this study. The saxon test was performed to measure the ASS. Results After a correction for age by ANCOVA, ASS in the anti-U1RNP-positive group was significantly lower than ASS in the control group (p <0.001). In the control group, ASS was not significantly decreased with advanced age (r=-0.140, p=0.211). In the anti-U1RNP-positive group, ASS was decreased with age, without a significant difference (r=-0.379, p=0.100). In the next analysis, we introduced ASS with age correction, assuming that all subjects in the anti-U1RNP-positive group were 49 years of age. A negative correlation between the titers of anti-U1RNP antibodies and the ASS with the age correction in the anti-U1RNP-positive group was noted (r=-0.520, p=0.019). The log of the antinuclear antibodies titers, or titers of rheumatoid factor was significantly correlated with the titers of anti-U1RNP antibodies, respectively (r=0.466, p=0.038 and r=0.595, p=0.006; respectively). The pathological findings of minor salivary gland biopsy in 2 subjects were compatible with Sjögrens syndrome; one subject showed moderate lymphocytic infiltration. Conclusion The presence of anti-U1RNP antibodies is associated with reduced ASS.
著者
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HORIKOSHI Hideyuki
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College
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OHSUZU Fumitaka
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College
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Suzuki Kimihiro
Department Of Internal Medicine Division Of Rheumatology National Defense Medical College
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Takada Kunio
Department Of Internal Medicine Division Of Rheumatology National Defense Medical College
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Ohsuzu Fumitaka
Department Of Internal Medicine 1^<st> National Defense Medical College
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Matsumoto Mitsuyo
Department Of Applied Biological Science Tokyo Noko University
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Higuchi Tomoaki
Department Of Internal Medicine Division Of Rheumatology National Defense Medical College
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Horikoshi Hideyuki
Department Of Internal Medicine Division Of Rheumatology National Defense Medical College
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Okada Makoto
Department Of Earth Sciences Ibaraki University
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Nakanishi Takashi
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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