Cardiac .BETA.-Adrenergic Signaling Pathway Alteration in Isoproterenol-induced Cardiac Hypertrophy in Male Sprague-Dawley Rats.
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概要
- 論文の詳細を見る
Isoproterenol was continuously administered to rats at a rate of 2.5μg/kg/min for 7 days via subcutaneously implanted osmotic minipumps. This treatment induced cardiac hypertrophy with increases in heart rate and systolic blood pressure.β-adrenoceptor (β-AR) density decreased in hypertrophied hearts, but the affinity for 125I-cyanopindolol did not change. The β-AR density decrease did not accompany the change in expression of β1-AR mRNA. In hypertrophied hearts, adenylyl cyclase activities in the steady state, and stimulated with isoproterenol, forskolin, and manganese, decreased but there was no change in the expression of adenylyl cyclase type V mRNA. The results suggest that β-AR downregulation and adenylyl cyclase desensitization in isoproterenol-induced cardiac hypertrophy are caused by post-transcriptional changes.
- International Heart Journal刊行会の論文
著者
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Ohsuzu Fumitaka
Department Of Internal Medicine 1^<st> National Defense Medical College
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Nakamura Haruo
Department Of Cardiovascular Surgery Toranomon Hospital
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HAMADA Hiroaki
Department of Biomolecular Engineering, Tokyo Institute of Technology
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HAKAMATA Naohiro
Department of Medicine I, National Defense Medical College
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