SERUM DESMOSTEROL AND OTHER LIPIDS IN MYOTONIC DYSTROPHY:A POSSIBLE PATHOGENESIS OF MYOTONIC DYSTROPHY
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that several inhibitors of cholesterol biosynthesis can induce myotonia, cataract and baldness, which are frequently observed in myotonic dystrophy, in man and experimental animals with concomitant accu-mulation of desmosterol.These observations suggest that the abnormal lipid metabolism play a pathogenetic role in myotonic dystrophy.The results of this study showed significantly elevated serum desmosterol, total cholesterol and triglyceride in myotonic dystrophy, indicating a possibility of pathogenetic role of abnormal lipid metabolism in this disease.
- The Keio Journal of Medicineの論文
著者
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Ito Kiyoaki
Department Of Clinical Molecular Informative Medicine Nagoya City University Graduate School Of Medi
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Goto Yuichiro
Department Of 1st Internal Medicine Tokai University School Of Medicine
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Nakamura Haruo
Department Of Cardiovascular Surgery Toranomon Hospital
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GOTO YUICHIRO
Department of Internal Medicine, School of Medicine, Keio University
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WAKAMATSU HIDEO
Department of Internal Medicine, School of Medicine, Keio University
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SHIGENO KOJI
Department of Internal Medicine, School of Medicine, Keio University
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ITO KIYOAKI
Department of Internal Medicine, School of Medicine, Keio University
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ANAZAWA WAKO
Department of Internal Medicine, School of Medicine, Keio University
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OKAJIMA SHIGETAKA
Department of Internal Medicine, School of Medicine, Keio University
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OKAMOTO SHIGEMICHI
Department of Internal Medicine, School of Medicine, Keio University
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