THE EFFECTS OF CHLORPROMAZINE ON CEREBRAL CIRCULATION AND METABOLISM

概要

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Cerebral circulatory measurements were made using the nitrous oxide method in six patients before and after administration of chlorpromazine, and the changes of cerebral hemodynamics, gaseous and glucose metabolism of brain and of electrolyte in hypotensive and soporific state by this drug were studied. Generally CBF, CMRO2 and CRQ were not significantly changed, CVR decreased and CMRgl was remarkably increased. The individual sensibilities to chlorpromazine were variable, so considerable attention must be paid to the significant hypotensive effects of this drug.The adequate adaptability of the cerebral hemodynamics was observed in the hypotensive state but the adaptability was depended upon the cerebral vascular change as well as in the administration of the hypotensive agents, so in the usage of chlorpromazine to the patients of cerebral vascular disturbance must be careful to falls of blood pressure.Comparing the cerebral hemodynamics at soporific state after administration of chlorpromazine with that of other states of unconsciousness the mechanism of unconsciousness by chlorpromazine was different from that of some comatose state accompanied with marked impairment of cerebral metabolism and rather resembled to the mechanism of natural sleep.
The Keio Journal of Medicineの論文