CONCENTRATIONS AND ELECTROPHORETICAL MIGRATIONS OF SERUM GLYCOPROTEINS IN NORMAL, OBESE, AND ARTERIOSCLEROTIC SUBJECTS

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1) The concentrations and the fractions of serum glycoproteins were meas-ured in normal, obese, and arteriosclerotic subjects.2) The levels of serum P.B.H. and seromucoid showed a tendency of in-creasing with aging. The concentrations of both serum P.B.H. and seromucoid in the middle aged normal subjects were significantly higher than those in the normal young, but were not significantly lower than those in the aged group.3) In the middle aged obese group, the serum P.B.H. and the seromucoid levels were significantly elevated than control values. Significant possitive correlations between serum glycoprotein (both serum P.B.H. and seromucoid) levels and the obesity indexes were observed.4) In the arteriosclerotic subjects, as a whole, only the mean value of seromucoid was significantly elevated than the control value. The arterios-clerotic patients were divided into two groups, the middle aged and the aged. In the middle aged arteriosclerotic group, the serum P.B.H. level was significantly increased. The slight elevation of the seromucoid level in this group was not statistically significant. On the contrary, in the aged arteriosclerotic group with or without cerebrovascular accident, the seromucoid level was markedly increased. The serum P.B.H. level of patients with history of cerebrovascular accident was significantly elevated in those who were fed well, and was reduced in those who could not take sufficient diet due to serious motor disturbances.5) The electrophoretical migration of serum glycoproteins was changed with aging. The albumin fraction was significantly decreased and the a-1 globulin fraction was significantly increased in the aged group compared with those values in the young group. The values of those fractions in the middle aged group were intermediate.6) The electrophoretical migration of serum glycoproteins showed no change in the middle aged obese subjects.7) The a-1 globulin fraction of serum glycoproteins was significantly increased in the arteriosclerotic subjects. In the middle aged arteriosclerotic group, the albumin fraction was significantly decreased, and the a-1 globulin fraction was significantly increased compared with the control value. In the aged arteriosclerotic group, a significantly increased a-1 globulin fraction was observed.8) The concentrations of serum P.B.H. and seromucoid of the same indivi-dual were not different in the morning or in the afternoon.
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