Age-related Effects of Norepinephrine on Rat Ventricular Hypertrophy.
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概要
- 論文の詳細を見る
Norepinephrine (NE) (2.5μg/kg/min) was administered to 5-week-old male Sprague Dawley rats by subcutaneous osmotic mini pumps for 14 days to generate an in vivo cardiac hypertrophy model and the responses with respect to aging examined. In the model, ventricles were significantly hypertrophied without myocardial necrosis and without significant increases in heart rate or blood pressure; the beta adrenergic system was down-regulated. In 37-week-old rats receiving 1.0μg/kg/min NE, there was a tendency towards heart failure, and myocardial necrosis and interstitial fibrosis were revealed by histological examinations. The density of beta adrenergic receptors and adenylyl cyclase activity was lower in the older rats. The excess stimulation of adrenergic receptors caused severe cardiac injury in old rats regardless of down regulation of beta adrenergic receptors.
- International Heart Journal刊行会の論文
著者
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Ohsuzu Fumitaka
Department Of Internal Medicine 1^<st> National Defense Medical College
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Nakamura Haruo
Department Of Cardiovascular Surgery Toranomon Hospital
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Ohsuzu Fumitaka
Department of Medicine I, National Defense Medical College
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HAMADA Hiroaki
Department of Biomolecular Engineering, Tokyo Institute of Technology
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HAKAMATA Naohiro
Department of Medicine I, National Defense Medical College
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HAMADA Hiroaki
Department of Medicine I, National Defense Medical College
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