Protective Effects of Verapamil and Adenosine Treatment on High Energy Phosphate Metabolism in Ischemic and Reperfused Myocardium.

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概要

• 論文の詳細を見る

• Isolated rat hearts were subjected to retrograde perfusion to investigate the protective effects of adenosine and verapamil on the myocardium. In group 1, the perfusate was standard Krebs-Henseleit buffer solution. The perfusate was changed to Krebs-Henseleit buffer containing verapamil (100nM) in group 2, adenosine (100μM) in group 3 and both drugs in combination in group 4 for 30min before ischemia and during 20min of reperfusion. Group 2 displayed a recovery of creatine phosphate but not of ATP at the end of reperfusion. In group 4, the recovery of both ATP and creatine phosphate was significantly greater than in group 1. The coronary flow of group 4 was significantly higher than that of the other groups. Treatment with both verapamil and adenosine before and after global ischemia may protect the ischemic myocardium by improving high energy phosphate metabolism and coronary circulation.

• International Heart Journal刊行会の論文

著者

• Aosaki Noboru

  Department Of Internal Medicine Kasumigaura National Hospital

• Ohsuzu Fumitaka

  Department Of Internal Medicine 1^<st> National Defense Medical College

• YANAGIDA Shigeki

  Department of Medicine I, National Defense Medical College

• Nakamura Haruo

  Department Of Cardiovascular Surgery Toranomon Hospital

• Takayama Eiichi

  Department Of Cardiology Mishuku Hospital

• Akanuma Masahiko

  Department Of Cardiology Self Defense Central Hospital

• Yanagida Shigeki

  Department Of Medicine I National Defense Medical College

• Hayashi Katsumi

  Department Of Gastroenterology Nagoya Daini Red Cross Hospital

• AOSAKI Noboru

  Department of Medicine I, National Defense Medical College

• MAIE Shinichi

  Department of Medicine I, National Defense Medical College

• SAKATA Nobuhiro

  Department of Medicine I, National Defense Medical College

• HAYASHI Katsumi

  Department of Medicine I, National Defense Medical College

• Hayashi Katsumi

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

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