Isolation of Antioxidative Phenolic Glucosides from Lemon Juice and Their Suppressive Effect on the Expression of Blood Adhesion Molecules
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概要
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Phenolic glucosides having radical scavenging activity were examined from the fraction eluted with 20% methanol on Amberlite XAD-2 resin applied to lemon (Citrus limon) juice by using reversed phase chromatography. Four phenolic glucosides were identified as 1-feruloyl-β-D-glucopyranoside, 1-sinapoyl-β-D-glucopyranoside, 6,8-di-C-glucosylapigenin and 6,8-di-C-glucosyldiosmetin by 1H-NMR, 13C-NMR, and MS analyses. They exhibited radical scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide, although the activity was low in comparison with eriocitrin, a potent antioxidant in lemon fruit, and the eriodictyol of its aglycone. The phenolic compounds in lemon juice were examined for their suppressive effect on the expression of blood adhesion molecules by measuring the expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) induced by necrosis factor-α (TNF-α). 6,8-Di-C-glucosylapigenin, apigenin, and diosmentin of the flavones were found to significantly suppress the expression of ICAM-1 at 10 μM (P<0.05). The phenolic glucosides isolated in this study were contained in comparative abundance in daidai (Citrus aurantium) and niihime (Citrus unshiu × Citrus tachibana) among the sour citrus juices.
- 社団法人 日本農芸化学会の論文
著者
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MIYAKE Yoshiaki
Faculty of Human Wellness, Tokaigakuen University
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OSAWA Toshihiko
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
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HIRAMITSU Masanori
Pokka Corporation Ltd.
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MORIMITSU Yasujiro
Laboratory of Food Chemistry, Graduate School of Humanities and Sciences, Ochanomizu University
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MOCHIZUKI Mika
Faculty of Human Wellness, Tokaigakuen University
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OKADA Miki
Pokka Corporation Ltd.
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