Antioxidative Pyranonigrins in Rice Mold Starters and Their Suppressive Effect on the Expression of Blood Adhesion Molecules

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概要

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• Antioxidants having a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity in rice mold starters, which are used for the preparation of various Japanese fermented foods, and their effectiveness against the expression of blood adhesion molecules were examined. An antioxidant was isolated from the rice mold starters used for shochu and identified as pyranonigrin-S (PG-S) by 1H-NMR, 13C-NMR, and FAB-MS analyses. It was a derivative of pyranonigrin-A (PG-A), which has been isolated as an antioxidant from the rice mold starters. Pyranonigrins PG-A and PG-S were found to exist in spores on rice mold starters which had been prepared by Aspergillus awamori, A. kawachii, and A. saitoi. PG-S exhibited a higher level of DPPH radical scavenging activity than PG-A. PG-A was found to have a significant suppressive effect on the expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-α (TNF-α) (P<0.05).

• 社団法人 日本農芸化学会の論文

著者

• MIYAKE Yoshiaki

  Faculty of Human Wellness, Tokaigakuen University

• OSAWA Toshihiko

  Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University

• ITO Chihiro

  Faculty of Pharmacy, Meijo University

• ITOIGAWA Masataka

  Faculty of Human Wellness, Tokaigakuen University

• MOCHIZUKI Mika

  Faculty of Human Wellness, Tokaigakuen University

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• Isolation of the Antioxidant Pyranonigrin-A from Rice Mold Starters Used in the Manufacturing Process of Fermented Foods
• Isolation of Antioxidative Phenolic Glucosides from Lemon Juice and Their Suppressive Effect on the Expression of Blood Adhesion Molecules

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