Application of Tumbling Melt Granulation Method to Prepare Controlled-Release Beads by Coating with Mixture of Functional Non-meltable and Meltable Materials

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概要

• 論文の詳細を見る

• A new coating method for use in preparing controlled-release beads was developed by modifying the tumbling melt granulation technique. The dissolution rate of the drug from the beads was controlled by coating the mixture of meltable and non-meltable materials by heating in a centrifugal fluidizing granulator without using any solvent. In experiments using talc as the non-meltable material, the resultant beads showed the sufficient ability to suppress the dissolution of the drug and no change in the dissolution characteristics by wetting agent and in a stability test at high temperature. Using functional polymer as the non-meltable material, the controlled-release beads with various dissolution characteristics could be prepared : entero-soluble-release beads using entero-suluble polymer, and zero-order-release beads using hydrophilic gel-forming agent and talc.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• KOBAYASHI MASAO

  Pharmaceutics Division Department, Product & Technology Development Laboratory, Tanabe Seiyaku Co.,

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• Osawa T

  Laboratory Of Food And Biodynamics Nagoya University Graduate School Of Bioagricultural Sciences

• Osawa T

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Osawa Takashi

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi Masao

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kobayashi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• MAEJIMA Toru

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 小林 資正

  Graduate School Of Pharmaceutical Sciences Osaka University

• Maejima T

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Maejima Toru

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

• Osawa Takashi

  Pharmaceutics Department Cmc Research Laboratory Tanabe Seiyaku Co Ltd

• NAKAJIMA Kingo

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Kawaguchi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• Nakajima K

  Sankyo Co. Ltd. Tokyo Jpn

• Nakajima Kingo

  Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.,

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