Saponin and Sapogenol. XXVII. Revised Structures of Holotoxin A and Holotoxin B, Two Antifungal Oligoglycosides from the Sea Cucumber Stichopus japonicus SELENKA

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概要

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• The chemical structures of two antifungal oligoglycosides holotoxin A and B, which were isolated from the sea cucumber Stichopus japonicus SELENKA, have been reinvestigated. On the basis of chemical and physicochemical evidence, the genuine sapogencl of holotoxin A and B has been elucidated to be holotoxigenol rather than previously proposed stichopogenin A_4 (3), and it has been shown that the structures of holotoxin A and B should be revised as 3-O-{2-O-[3-O-methyl-β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl-(1→4)-β-D-quinovopyranosyl]-4-O-[3-O-methyl-β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl]-β-D-xylopyranosyl}-holotoxigenol (6) and 3-O-{2-O-[3-O-methyl-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl (1→4)-β-D-quinovopyranosyl]-4-O-[β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl]-β-D-xylopyranosyl}-holotoxigenol (9), respectively.

• 公益社団法人日本薬学会の論文
• 1978-12-25

著者

• 吉岡 一郎

  Tsumura Laboratory

• 吉岡 一郎

  Faculty Of Pharmaceutical Sciences Osaka University

• 西野 隆雄

  Faculty of Pharmaceutical Sciences, Osaka University

• 西野 隆雄

  大阪薬科大学

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• 菅原 民雄

  Faculty of Pharmaceutical Sciences, Osaka University

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• 菅原 民雄

  Faculty Of Pharmaceutical Sciences Osaka University:(present Address)shionogi Research Laboratory Sh

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