Urine Data Analysis for Pharmacokinetics of Acetanilide Hydroxylation in Man

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概要

• 論文の詳細を見る

• It was demonstrated that acetanilide hydroxylation in man is saturated by as small as 0.5 g dose. Subjects ingested low dose (100 mg) and high dose (500 mg) of acetaminophen and acetanilide. Total acetaminophen (free and conjugated) excreted in urine was determined. Ratio of amount excreted (RAE) between two dose levels was calculated. Saturation of pharmacokinetic process was verified by the value of regression coefficient of RAE to t.

• 公益社団法人日本薬学会の論文
• 1976-07-25

著者

• 柴崎 寿一郎

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 吉岡 一郎

  Tsumura Laboratory

• 吉岡 一郎

  Faculty Of Pharmaceutical Sciences Osaka University

• 小泉 保

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 小泉 保

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 上田 道広

  Faculty of Pharmaceutical Sciences, University of Toyama

• 浅見 茂

  Faculty of Pharmaceutical Sciences, University of Toyama

• 上田 道廣

  富山大学薬学部

• 浅見 茂

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 柴崎 寿一郎

  Faculty of Pharmaceutical Sciences, Nagasaki University

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