Relationship between Blood Levels and Analgesic Effects of Acetaminophen in Mice
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概要
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The relationship between time course of blood level of acetaminophen (NAPA) and time-analgesic effect course was examined in mice after intravenous and subcutaneous administration of NAPA in doses of 149,200,268,and 360 mg/kg. The results obtained were as follows. (1) When the effect and the corresponding blood level obtained from time course studies of 4 kinds of doses were examined together, their relationship seemed to be rather poor. Namely, like blood level due to different doses produces no like effect. (2) When only the data after the peak effect were examined for each dose, respectively, higher relationship was found both in intravenous and subcutaneous studies. It was also found that with increasing of doses, the rate at which effect decreased from the peak became faster and higher blood level came to be necessary for obtaining a certain level of effect. (3) comparing the time course data at the same doses, the effects after subcutaneous administration were always lower than those after intravenous administration even when NAPA blood level after subcutaneous administration were higher, suggesting that effect of NAPA might not depend on NAPA level in the blood or in the site of action at the time when effect was measured but rather on the peak NAPA level there and the elapse of time. (4) In conclusion, the relationship observed under a variety of doses and administration routes of NAPA is so complicated that even the possibility that analgesic effect elicited by this drug may be inherently beyond the limits of kinetic explanation cannot be ruled out.
- 公益社団法人日本薬学会の論文
- 1979-01-25
著者
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柴崎 寿一郎
Faculty Of Pharmaceutical Sciences Nagasaki University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小西 良士
帝國製薬(株)研究開発本部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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北崎 直
Faculty of Pharmaceutical Sciences, Nagasaki University
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北崎 直
Faculty Of Pharmaceutical Sciences Nagasaki University
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柴崎 寿一郎
Faculty of Pharmaceutical Sciences, Nagasaki University
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