Biological Effects of Furosemide in Relation to Its Disposition in Rabbits
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概要
- 論文の詳細を見る
The purpose of this study was to represent quantitatively the relationship between the time course of pharmacological response and drug disposition data after intravenous administration of furosemide in rabbits. After administration of furosemide, urine flow rate, urinary excretion rate of Na^+ and K^+ were measured as well as excretion rate of intact drug and drug plasma level. From the data observed, a simplified simulation model was constructed and theoretical values were calculated by the model. Calculated values showed reasonable coincidence with the observed values. The urinary excretion rate of furosemide which was used in place of the plasma level, for the practical purposes, was able to correlate quantitatively with diuretic response ; urine flow rate and electrolyte excretion rate.
- 公益社団法人日本薬学会の論文
- 1977-09-25
著者
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小泉 保
富山医科薬科大学
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片山 和憲
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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掛見 正郎
Faculty of Pharmaceutical Sciences
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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掛見 正郎
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kawasaki M
Department Of Biological Pharmaceutical Sciences College Of Pharmacy Nihon-university
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上田 道広
Faculty of Pharmaceutical Sciences, University of Toyama
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福地 滋夫
Faculty of Pharmaceutical Sciences, University, of Toyama
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上田 道廣
Faculty of Pharmaceutical Sciences, University, of Toyama
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上田 道廣
富山医科薬科大学薬学部
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上田 道廣
富山大学薬学部
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上田 道廣
Faculty Of Pharmaceutical Sciences University Of Toyama
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福地 滋夫
Faculty Of Pharmaceutical Sciences University Of Toyama
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