A Study of the Hydrophilic Cellulose Matrix : Effect of Drugs on Swelling Properties
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概要
- 論文の詳細を見る
The swelling properties of hydrophilic cellulose matrices were studied using three drugs having different water solubility : indomethacin, theophylline, and mannitol. Two swelling parameters : maximum swelling index (V) and the apparent diffusion coefficient of water in the matrix (D_w), were calculated from the swelling data and were used to describe structures and properties of the swollen matrices. The V value indicates the swelling extent as well as the capacity of maintaining the matrix shape, whereas D_w represents the swelling rate that also reflects the structural resistance of the polymer network against the movement of water molecules. The results show that both polymers and incorporated drugs influence the swelling properties of the matrices. Polymers that contain more hydroxypropoxyl group produce matrices with high integrity, even in the presence of drugs. V values indicated that the capacity of the matrices to maintain their shape depends on polymer (i.e., the swelling part). The effect of drug solubility can be seen from D_w values. For a highly water-soluble drug, the structural resistance of the swollen matrices is mainly governed by the drug. In contrast, this primarily influenced by the polymer in the case of drugs that are slightly or poorly water soluble.
- 社団法人日本薬学会の論文
- 1996-05-15
著者
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KATAYAMA Kazunori
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KOIZUMI Tamotsu
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Koizumi T
Toyama Medical & Pharmaceutical Univ. Toyama Jpn
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Katayama K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Katayama K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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HATANAKA Tomomi
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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PANOMSUK Suwannee
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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AIBA Tetsuya
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Hatanaka Tomomi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Hatanaka Tomomi
Faculty Of Pharmaceutical Sciences Josai University
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Koizumi T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Aiba T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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合葉 哲也
富山医薬大・薬
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Aiba Tetsuya
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Panomsuk Suwannee
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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