A NOTE ON SATURABLE AND INHIBITORY KINETICS OF p-AMINOHIPPURATE RENAL TRANSPORT IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
In order to establish quantitative expressions of inhibitory kinetics in renal tubular secretion of p-aminohippurate (PAH), bolus i.v. injection and constant i.v. infusion of PAH were loaded to rabbits. Time courses of plasma concentration and urinary excretion rate were analyzed using compartment model with saturable rate process. Effects of sulfamethizole (SMZ) constant infusion and bolus injection on PAH renal excretion were also examined. Multi-compartment model for concurrent disposition of PAH and SMZ is presented. Excretory processes are composed of non-saturable filtration, saturable secretion which is subject to mutual inhibition, and reabsorption.
- 公益社団法人日本薬学会の論文
著者
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KATAYAMA Kazunori
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KAKEMI Masawo
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KOIZUMI Tamotsu
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Katayama K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kakemi Masawo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi Masao
大阪薬科大学 薬剤学
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Koizumi T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Shirai Yoko
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Takatsuki Jpn
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KOSHI KATSUTOSHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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UEDA MICHIHIRO
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Koshi Katsutoshi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Ueda Michihiro
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:(presents Address) F
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