ラットにおけるSuccinylcholineの筋弛緩効果におよぼす血清Cholinesterase活性の影響
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概要
- 論文の詳細を見る
Effects of serum cholinesterase activity on muscle relaxation caused by succinylcholine were examined in rats. By using acetylthiocholine as substrate, serum cholinesterase activity was estimated colorimetrically. For pharmacologic response, the twitch hight of tibialis anterior muscle caused by electrical stimulation of sciatic nerve was determined. Correlations between serum cholinesterase activity and maximal relaxation or between serum cholinesterase activity and recovery time to 10% response were not significant. A negative correlation, though not significant, was observed between serum cholinesterase activity and area under response time curve with higher dose level (0.3 and 0.4 mg/kg). It was concluded that interindividual variation of serum cholinesterase activity has no significant effect on pharmacologic response to succinylcholine in rats.
- 社団法人日本薬学会の論文
- 1984-04-25
著者
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小泉 保
富山医科薬科大学
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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Kakemi M
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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掛見 正郎
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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北村 和則
富山医科薬科大学薬学部
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片山 和憲
富山医科薬科大学薬学部
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掛見 正郎
富山医科薬科大学薬学部
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kawasaki M
Department Of Biological Pharmaceutical Sciences College Of Pharmacy Nihon-university
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片山 和憲
富山医科薬科大学
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