Pharmacokinetic Analysis of Pharmacological Effects and Drug Disposition. II. Effects of Salicylamide on Afebrile Rats

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概要

• 論文の詳細を見る

• The purpose of this investigation was to represent quantitatively the relationship between the time course of pharmacological effects and drug disposition data after oral administration of salicylamide, an antipyretic drug, in normal (afebrile) rats, using pharmacokinetic method. After administration of salicylamide, rectal temperature and skin temperature were measured continuously, and the changes in metabolic heat production rate and in vaporization heat loss rate were also measured by indirect calorimetry. The blood concentration of salicylamide versus time course was determined as the drug disposition data. From the observed data, an electrical analog was constructed to simulate the effects of salicylamide including physiological thermoregulation in afebrile rats. The results indicate that the time course of pharmacological effects of salicylamide are reasonably simulated by a mathematical model.

• 公益社団法人日本薬学会の論文
• 1976-09-25

著者

• 小泉 保

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 掛見 正郎

  Faculty of Pharmaceutical Sciences

• 小泉 保

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kakemi M

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

• 上田 道広

  Faculty of Pharmaceutical Sciences, University of Toyama

• 小林 丈子

  Faculty of Pharmaceutical Sciences, University of Toyama

• 真室 千穂子

  Faculty of Pharmaceutical Sciences, University of Toyama

• 上田 道廣

  富山大学薬学部

• 小林 丈子

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 真室 千穂子

  Faculty Of Pharmaceutical Sciences University Of Toyama

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