高周波パルス型イオントフォレシスによるフマル酸フォルモテロールの経皮吸収促進(第1報) : 一定電流及び一定電圧の影響
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概要
- 論文の詳細を見る
The effect of iontophoresis on percutaneous absorption of formoterol fumarate (FF) was investigated in vitro with abdominal skin excised from guinea pig. By passive diffusion, the flux at steady state for stripped skin was about 230 times greater than that for intact skin. Therefore, it is suggested that stratum corneum is a barrier for the percutaneous absorption of FF. Penetrated amount of FF increased significantly with an increase in donor concentration from 0.035% to 0.07%. Under the constant current iontophoresis the large flux accompanied with the high applied voltage was shown at the beginning of iontophoresis. Thereafter the flux decreased with a decrease in applied voltage. Under the constant voltage iontophoresis a linear relationship between penetrated amount of FF and time was observed.
- 公益社団法人日本薬学会の論文
- 1989-10-25
著者
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小泉 保
富山医科薬科大学
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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Kakemi M
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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掛見 正郎
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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片山 和憲
富山医科薬科大学薬学部
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掛見 正郎
富山医科薬科大学薬学部
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kawasaki M
Department Of Biological Pharmaceutical Sciences College Of Pharmacy Nihon-university
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稲田 裕彦
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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摺出寺 一喜
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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川崎 正夫
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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摺出寺 一喜
救急薬品工業株式会社
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稲田 裕彦
富山医科薬科大学薬学部
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川崎 正夫
救急薬品工業株式会社
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稲田 裕彦
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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川崎 正夫
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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摺出寺 一喜
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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片山 和憲
富山医科薬科大学
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