PHARMACOKINETIC EVIDENCE FOR BLOOD FLOW DEPRESSION IN DOSE DEPENDENT DISPOSITION OF 4-AMINOANTIPYRINE IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacokinetic relationships have been developed to characterize a one-compartment drug disposition model which includes perfusion limited elimination processes. The derived expressions have been applied to plasma concentration and urinary excretion data obtained after rapid intravenous administration of 4-aminoantipyrine to rabbits. The mathematical relationships and experimental data demonstrate that dose dependent disposition of 4-aminoantipyrine is a result of reduced renal and hepatic blood flow caused by the drug itself.
- 公益社団法人日本薬学会の論文
著者
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KATAYAMA Kazunori
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KAKEMI Masawo
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KOIZUMI Tamotsu
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Katayama K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kakemi Masawo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi Masao
大阪薬科大学 薬剤学
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Koizumi T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Murai Atsuko
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Takatsuki Jpn
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MITSUYAMA SHUMPEI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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MASUMI ATSUKO
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Mitsuyama Shumpei
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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