A KINETIC STUDY ON CHLORPROMAZINE DISPOSITION AND HYPOTHERMIC RESPONSE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacokinetic relationships were developed to characterize a multi-exponential drug disposition and pharmacologic response time courses. The derived expressions were applied to serum and cerebral concentrations and the hypothermic response data, which were obtained after rapid intravenous administration of chlorpromazine hydrochloride to rats. The results of this study indicate that the magnitude of the pharmacologic effects of chlorpromazine such as decrease in metabolic heat production and increase in tail blood flow, at a given time, are logarithmic logistic functions of the cerebral chlorpromazine concentration at that time.
- 公益社団法人日本薬学会の論文
著者
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KATAYAMA Kazunori
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KAKEMI Masawo
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KOIZUMI Tamotsu
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Katayama K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kakemi Masawo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi Masao
大阪薬科大学 薬剤学
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SATO Shinji
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Koizumi T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kakemi M
Osaka Univ. Pharmaceutical Sci. Takatsuki Jpn
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NAKAGAWA IKUKO
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Nakagawa I
Hiroshima Univ. Higashi‐hiroshima
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Sato Shinji
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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