A Study of the Hydrophilic Cellulose Matrix : Effect of Indomethacin and a Water-Soluble Additive on Release Mechanisms
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概要
- 論文の詳細を見る
The release profile of indomethacin (IM) from a direct compressible matrix containing three hydrophilic cellulose derivatives, methylcellulose (MC25 and MC50), hydroxypropylcellulose (HPC140), and hydroxypropylmethylcellulose (HPMC50) was studied. The drug release profile was affected by matrix size, polymer type, drug : polymer ratio and water soluble additive (lactose). An IM zero-order release matrix can be obtained by mixture and direct compression with MC50,HPMC50 and HPC140. The release rate from the MC50 and HPC140 matrix can be modified by replacing MC50 or HPC140 with MC25,and a zero-order release could be obtained even when the amount of replacement with MC25 is up to 35 and 45%, respectively. Lactose up to 10% slightly affected the release profile. IM released from this kind of matrix by a zero-order rate seems to be controlled by the swelling and relaxation of the polymer.
- 公益社団法人日本薬学会の論文
- 1995-06-15
著者
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小泉 保
富山医科薬科大学
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畑中 朋美
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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合葉 哲也
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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片山 和憲
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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PANOMSUK Suwannee
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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畑中 朋美
富山医薬大 薬
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畑中 朋美
Faculty Of Pharmaceutical Sciences:josai University
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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合葉 哲也
富山医薬大・薬
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Panomsuk Suwannee
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Panomsuk S
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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