Bioavailability of Morphine in Rabbits after Rectal Administration of Suppository Containing Controlled Release Morphine Tablet
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概要
- 論文の詳細を見る
Two kinds of sustained release morphine suppositories have been prepared; one is an oleaginous base suppository (MSC) containing a controlled release morphine tablet (MST : MS Contin), and the other is a hollow-type suppository (MSCH) containing MST and morphine powder packed in its hollow space. In vitro release tests and in vivo rectal absorption experiments in rabbits were performed. The profiles of morphine release from MST and MSC in vitro were similar, and revealed that suppository bases had no effect on the release profile of morphine from the preparation. Morphine release from MSCH was rapid in the early phase, and then enclosed morphine was slowly and continuously released from MST. Pharmacokinetics of morphine from the suppository were compared with the orally administered MST, and it was found that there was no difference in the maximum plasma concentration (C_<max>) and the peak time (T_<max>) between MSC and MST, but the mean residence time (MRT) of MSC was approximately three times longer than that of MST, and the extent of bioavailability (BA) of MSC was significantly larger than that of MST (71.6±14.2% and 11.9±4.0%, respectively). C_<max> can be altered arbitrarily by changing the morphine content in the hollow space of MSCH. As in the case of MSC, the plasma concentration of morphine from MSCH was maintained.It is concluded from the above results that MSC is a satisfactory sustained release morphine suppository for the treatment of cancer pain, administering it twice a day, and that MSCH is effective due to its fast analgesic effect and sustained release nature not only for cancer pain but also for surgical operations.
- 公益社団法人日本薬学会の論文
- 1992-07-25
著者
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小泉 保
富山医科薬科大学
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堀越 勇
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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堀越 勇
富山医科薬科大学附属病院薬剤部
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足立 伊佐雄
富山医科薬科大学生命科学実験センター
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上野 雅晴
富山医薬大 薬
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小泉 保
富山医科薬科大学薬学部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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足立 伊佐雄
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical Univeristy
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鄭 年新
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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金本 郁男
Department of Pharmacy, Hokuriku Central Hospital
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鄭 年新
富山医科薬科大学・附属病院薬剤部
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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堀越 勇
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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上野 雅春
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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金本 郁男
公立学校共済組合北陸中央病院薬剤部
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上野 雅春
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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