Studies on Metabolism of Drugs. XI. A New Metabolite of Sulfaphenazole in Man. (2)

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概要

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• In order to elucidate the unknown metabolite found in the human urine after ingestion of sulfaphenazole, the urine was treated with Dowex 2 and 50,purified by basic lead acetate treatment, and finally separated by paper chromatography. The product was obtained as colorless prisms of mp 185-188° (decomp.). The ring-N-glucuronide of sulfaphenazole was acetylated with acetic anhydride and pyridine, and purified through paper and column chromatography over Dowex 50W-X4. The colorless crystals thereby obtained were identical with the extracted product in mp, elemental analysis, paper chromatographic behavior, and ultraviolet and infrared spectra. Therefore, this metabolite was found to be ammonium 1-deoxy-[1-phenyl-5-(N^4-acetylsulfanilamino)-3-pyrazoline-2-yl]-D-glucopyranosiduronate with three moles of water of crystallization. It was assumed that sulfaphenazole is first acetylated at N^4-position and then the ring-N-glucuronide is formed in vivo.

• 公益社団法人日本薬学会の論文
• 1971-10-25

著者

• 小泉 保

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 小泉 保

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 上田 道広

  Faculty of Pharmaceutical Sciences, University of Toyama

• 折田 清

  Faculty of Pharmaceutical Sciences, University of Toyama

• 折田 清

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 上田 道廣

  富山大学薬学部

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