Factors Affecting Sulfisoxazole Transport through Excised Rat Skin during Iontophoresis
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概要
- 論文の詳細を見る
Permeation of sulfisoxazole (SIX) across the excised rat skin were studied using two chamber cell with four electrodes, under three successive experimental conditions : without current for 3 h (treatment I), with current for 4 h (treatment II) and without current for 3 h (treatment III). Transport of SIX was significantly increased by iontophoresis. The enhancement ratio of SIX flux were reasonably predicted by Coldman's equation. There was no significant difference (p<0.05) between the flux in treatent I and treatment III. On the basis of the flux reversibility, it was concluded that skin alteration did not occur when the applied electric potential was below 5.025 V. Although a prominent current-induced volume flow (from the anodal side to the cathodal side) was observed during current exposure, SIX flux was not influenced by the volume flow. The flux enhancement of SIX was mainly dependent on transdermal potential difference.
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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小泉 保
富山医科薬科大学
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片山 和憲
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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掛見 正郎
Faculty of Pharmaceutical Sciences
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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遠藤 真樹子
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kakemi M
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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掛見 正郎
Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Kawasaki M
Department Of Biological Pharmaceutical Sciences College Of Pharmacy Nihon-university
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稲田 裕彦
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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稲田 裕彦
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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