Mutual Inhibition in Hydroxylation of Acetanilide and N-Phenylurea in Rabbits

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概要

• 論文の詳細を見る

• Blood concentration of unchanged N-phenylurea and the urinary excreted amount of its metabolites were determined periodically, after intravenous administration of N-phenylurea. Blood concentration time course of N-pheylurea observed was well explained by a pharmacokinetic model that assumes Michaelis Menten equation for hydroxylation step and a first order process for the metabolism of N-phenylurea other than hydroxylation. This result is analogous to that of acetanilide reported previously. In addition, elimination rate of acetanilide from the blood was affected and reduced by the simultaneous administration of N-phenylurea. It was proved that the hydroxylation process of these drugs was mutually inhibited. Computation of the theoretical values were carried out by means of an analog computer.

• 公益社団法人日本薬学会の論文
• 1974-05-25

著者

• 柴崎 寿一郎

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 小泉 保

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 掛見 正郎

  Faculty of Pharmaceutical Sciences

• 小泉 保

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kakemi M

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

• 松本 祥子

  Faculty Of Pharmaceutical Sciences Medical School Okayama University

• 上田 道広

  Faculty of Pharmaceutical Sciences, University of Toyama

• 品川 龍太郎

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 上田 道廣

  富山大学薬学部

• 品川 龍太郎

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 柴崎 寿一郎

  Faculty of Pharmaceutical Sciences, Nagasaki University

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