Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin
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概要
- 論文の詳細を見る
The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions : (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.
- 社団法人日本薬学会の論文
- 1994-08-15
著者
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小泉 保
富山医科薬科大学
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加藤 安宏
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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田島 武志
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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畑中 朋美
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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合葉 哲也
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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片山 和憲
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小泉 保
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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片山 和憲
富山医薬大薬
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小泉 保
富山医科薬科大学薬学部
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小泉 保
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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畑中 朋美
富山医薬大 薬
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畑中 朋美
Faculty Of Pharmaceutical Sciences:josai University
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Katayama Kazunori
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Koizumi Tamotsu
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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Aiba T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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合葉 哲也
富山医薬大・薬
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田島 武志
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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