A Kinetic Study of Chlorpromazine on the Hyperglycemic Response in Rats. I. Effect of Chlorpromazine on Plasma Catecholamines

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概要

• 論文の詳細を見る

• The effect of chlorpromazine (0.5 and 4 mg/kg) on plasma catecholamines (adrenaline and noradrenaline) concentrations was investigated in rats. After an i.v. bolus administration of chlorpromazine, plasma adrenaline and noradrenaline concentrations showed a dose dependent increase. In order to clarify the pharmacokinetics of catecholamines in plasma, i.v. infusion of adrenaline or noradrenaline was also carried out. Plasma catecholamines after i.v. infusion showed typical characteristics of a one compartment model with a zero order production rate of endogenous catecholamines. From the data observed, a mathematical model was constructed to elucidate the relationship between the pharmacokinetics (brain concentrations) and the pharmacologic effect (plasma catecholamines concentrations) of chlorpromazine in rats. The results indicated that the time courses of plasma adrenaline and noradrenaline concentrations after an i.v. administration of chlorpromazine were described reasonably well by a simple pharmacokinetic-pharmacodynamic model.

• 社団法人日本薬学会の論文

著者

• KATAYAMA Kazunori

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• KAKEMI Masawo

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• KOIZUMI Tamotsu

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• ENDOH Makiko

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Koizumi T

  Toyama Medical & Pharmaceutical Univ. Toyama Jpn

• Endoh Makiko

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Endoh Makiko

  富山医科薬科大学 薬

• Katayama K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Katayama K

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kakemi Masawo

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kakemi M

  Department Of Pharmaceutics Osaka University Of Pharmaceutical Sciences

• Kakemi Masao

  大阪薬科大学 薬剤学

• HATANAKA Tomomi

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• SATO Shinji

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• MIZUNO Sumiko

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• OHSHIMA Kouichi

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Ohshima Kouichi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Hatanaka Tomomi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Hatanaka Tomomi

  Faculty Of Pharmaceutical Sciences Josai University

• Mizuno Sumiko

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Mizuno Sumiko

  富山医科薬科大学 薬

• Mizuno Sumiko

  Research Center Mitsubishi Kasei Co.

• Koizumi T

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Katayama Kazunori

  Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University

• Kakemi M

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Koizumi Tamotsu

  Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University

• Okuyama Kaori

  Department Of Pathophysiology Tohoku Pharmaceutical University

• Kakemi M

  Osaka Univ. Pharmaceutical Sci. Takatsuki Jpn

• Okuyama K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Sato Shinji

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kakemi M

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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