Intestinal Expression and Metabolic Activity of the CYP3A Subfamily in Female Rats(Biopharmacy)
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概要
- 論文の詳細を見る
The intestinal expression of the CYP3A subfamily was investigated in female rats, and the intestinal metabolism of two CYP3A substrates, testosterone and rifabutin, was examined and compared between males and females. CYP3A1/23 and CYP3A2 intestinal expression was barely detected in male and female rats. Although CYP3A9 was predominantly expressed in the female rat liver, its expression in the intestine was not different between the two sexes. The rate of testosterone 6β-hydroxylation in the female intestine was similar to that for males. Rifabutin was also metabolized at similar rates in both intestines, although the metabolic rate was greater in the female liver. These results indicate that the intestinal drug metabolizing activity of the CYP3A subfamily is similar between males and females, and that CYP3A9 is involved in the intestinal metabolism of CYP3A substrates in both sexes.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Aiba Tetsuya
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Aiba T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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合葉 哲也
富山医薬大・薬
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HASHIMOTO Yukiya
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Aiba Tetsuya
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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Ishida Kazuya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Hashimoto Yukiya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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YOSHINAGA Mariko
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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TAKEHARA Yutaka
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Yoshinaga M
Hoshi Coll. Pharmacy Tokyo Jpn
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Takehara Yutaka
Graduate School Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Hashimoto Y
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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