Population Pharmacokinetics of Higher-Dose Mizoribine in Healthy Male Volunteers(Biopharmacy)
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概要
- 論文の詳細を見る
The population pharmacokinetic parameters of mizoribine in healthy subjects were estimated using a nonlinear mixed effects model (NONMEM) program. Pharmacokinetic data for population analysis were obtained in the previous study, in which 24 healthy Caucasian male subjects participated in a single-dose (3, 6, 9, 12mg/kg) study, and 12 subjects participated in a multiple-dose (6, 12mg/kg/d) study. The mean value of the absorption lag time, absorption rate constant (KA), and apparent distribution volume (V/F) was estimated to be 0.349h, 0.869h^<-1>, and 0.834l/kg, respectively. Oral clearance (CL/F) was modeled with creatinine clearance (CLcr), and the mean value was estimated to be 1.93・CLcr l/h. In addition, pharmacokinetic parameters in individual 36 subjects were obtained from population estimates according to Bayes' theorem. Pharmacokinetic parameters (KA, V/F, and CL/F) in the single-dose study were almost constant at a dose range of 3-12mg/kg, and were similar to those in the multiple-dose study. These findings indicated that the pharmacokinetics of mizoribine is well described by a simple one-compartment model with first-order absorption.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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HASHIMOTO Yukiya
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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HONDA Mutsuko
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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Itoh Hiromichi
Asahi Kasei Pharma Corporation
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Honda Mutsuko
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Honda Mutsuko
Graduate School Of Pharmaceutical Sciences University Of Toyama
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Hashimoto Yukiya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Hashimoto Yukiya
Graduate School Of Pharmaceutical Sciences University Of Toyama
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SUZUKI Tadakiyo
Asahi Kasei Pharma Corporation
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