Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure

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概要

• 論文の詳細を見る

• Several tropolone derivatives(4-7)were designed as novel retinoids on the assumption that the tropolone ring may mimic the benzoic acid moiety in retinoid structures, such as Am80(2). Among the synthesized compounds, 5-[2-(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthyl)ethynyl]tropolone(7a)showed moderate potency as a differentiation-inducer of HL-60 cells. The activities of the tropolones were greatly enhanced in the presence of HX630, an RXR agonist(retinoid synergist).

• 公益社団法人日本薬学会の論文
• 2001-04-01

著者

• FUKASAWA Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• KAGECHIKA Hiroyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• OHTA Kiminori

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• KAWACHI Emiko

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• EBISAWA Masayuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Ebisawa Masayuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Fukasawa Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Ohya Kumiko

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Fukasawa H

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

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