Enhancing Effect of Tumor Promoters, Phorbol Esters and Teleocidins on Nuclear Receptor-Mediated Transcription

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概要

• 論文の詳細を見る

• Interaction between a tumor promoter, 12-O- tetradecanoylphorbol 13-acetate (TPA), and ligands of nuclear receptors has been interpreted as the result of crosstalk between the nuclear receptors and oncogenic transcription factor AP-1. We examined the effects of various tumor promoters on transcription mediated by several nuclear receptors (RAR, TR, and ROR) by using thymidine kinase promoter-based reporter systems. TPA-type and other types of tumor promoters (okadaic acid, thapsigargin) enhanced reporter gene transcription independently of the cognate ligands for the receptors. Various kinds of TPA-type tumor promoters, teleocidine and its synthetic derivatives (indolactam, benzolactams) enhanced reporter gene transcription in proportion to their differentiation-inducing activities. Although TPA is known to activate protein kinase C (PKC) , some PKC inhibitors did not inhibit the effect of TPA on reporter gene transcription. Interestingly, staurosporin, a strong PKC inhibitor and also a tumor promotor, enhanced the effect of TPA and weakly enhanced the reporter transcription itself. These results suggest this reporter system in useful for the evaluation of effects on the gene expression of various tumor promoters, including non-TPA type.

• 社団法人日本薬学会の論文
• 2000-12-01

著者

• 遠藤 泰之

  東北薬科大学薬学部

• FUKASAWA Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Hashimoto Y

  Univ. Tokyo Tokyo Jpn

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• ENDO Yasuyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• YAMAGUCHI Mitsuhiro

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Shudo K

  Research Foundation Itsuu Laboratory

• Fukasawa Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Yamaguchi M

  Gifu Pharmaceutical University

• Fukasawa H

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• 山口 雅久

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Endo Yasuyuki

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

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