New Estrogenic Antagonists Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore
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概要
- 論文の詳細を見る
We have designed and synthesized estrogen antagonists bearing dicarba-closo-dodecaborane (carborane) as a hydrophobic pharmacophore based on the structure of 1-(4-hydroxyphenyl)-1,12-dicarba-closo-dodecaborane, a potent estrogen agonist that we reported previously. Compounds with a long alkyl chain bearing an amide moiety on the carborane skeleton (6,7) showed estrogen antagonistic activity in a luciferase reporter gene assay using COS-1 cells tranfected with a rat ERα-espression plasmid and as an appropriate reporter plasmid.
- 社団法人日本薬学会の論文
- 2000-02-01
著者
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遠藤 泰之
東北薬科大学薬学部
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YAMAKOSHI Yuko
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Yamakoshi Yuko
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Yamakoshi Y
Univ. Tokyo Tokyo Jpn
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ENDO Yasuyuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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YOSHIMI Tomohiro
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Yoshimi Tomohiro
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Endo Yasuyuki
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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