ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS. SYNTHESIS AND ACTIVITY OF 9-ALKYLATED BENZOLACTAMS

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概要

• 論文の詳細を見る

• (-)-Benzolactam-V8-310 reproduces the active conformation and biological activity of teleocidins. Various sizes and shapes of alkyl groups on aromatic nucleus of BL-V8 were synthesized as optically pure forms. Structure-activity results indicate that hydrophobic substituents at C-9 position plays a critical role for the appearance of biological activities.

• 社団法人日本薬学会の論文
• 1996-05-15

著者

• 遠藤 泰之

  東北薬科大学薬学部

• ENDO Yasuyuki

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• SHUDO Koichi

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Shudo Koichi

  Faculty Of Pharmaceutical Science Kyushu University

• Hirano Masaaki

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• YAMAGUCHI Mitsuhiro

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Shudo K

  Research Foundation Itsuu Laboratory

• Yamaguchi M

  Gifu Pharmaceutical University

• 山口 雅久

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Endo Yasuyuki

  Faculty Of Pharmaceutical Sciences Tohoku Pharmaceutical University

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