Novel Antiasthematic Agents with Dual Activities of Thromboxane A_2 Synthetase Inhibition and Bronchodilation. IV.2-[2-(1-Imidazolyl)ethyl]-4-(3-pyridyl-1(2H)-phthalazinones

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概要

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• Synthesis and pharmacological evaluation of several compounds related to 2-[2-(1-imidazolyl)ethyl]-4-(3-pyridyl)-1(2H)-phthalazinones are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A_2 synthetase-inhibitory and bronchodilatory activities. Further, the 3-pyridyl group at the 4-position was shown to be necessary for in vivo thromboxane A_2 synthetase-inhibitory activity.

• 公益社団法人日本薬学会の論文
• 1994-09-15

著者

• 大井 信広

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 古賀 隆樹

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Yamaguchi M

  Gifu Pharmaceutical University

• 黒木 俊夫

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Koga T

  Daiichi College Of Pharmaceutical Sciences

• 丸山 典昭

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 亀井 研志

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 山口 雅久

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 秋間 通立

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 濱名 政和

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 山口 雅久

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 濱名 政和

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 秋間 通立

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 丸山 典昭

  Fuji-Gotemba Laboratories, Chugai Pharmaceutical, Co., Ltd.,

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