Preparation of Di-altro-β-cyclodextrins with Two Altrosides as the Macrocyclic Units through Selective Synthesis of Regioisomers of Di(2-O-mesitylenesulfonyl)-β-cyclodextrin

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概要

• 論文の詳細を見る

• Regioisomers of di(2-O-mesitylenesulfonyl)-β-cyclodextrin 2-4 were synthesized in 3,4 times larger yields compared to those of the reported method using dibutyltin oxide/triethylamine/p-toluenesulfonyl chloride. Regioisomers of di-mannoepoxy-β-cyclodextrin 5-7 were prepared from 2-4 and converted to the corresponding di-altro-β-cyclodextrins (8-10) with two altrosides as macrocyclic units, respectively. Conformations of the altrose parts of di-altro-β-cyclodextrins were investigated by NMR, and the altroside was found to change its conformation depending on whether or not it is a member of the macrocyclic ring and its position in the ring.

• 公益社団法人日本薬学会の論文
• 1997-04-15

著者

• Fujita K

  Tohoku Univ. Sendai Jpn

• IKEGAMI Yoji

  Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University

• OHTA Kazuko

  Faculty of Pharmaceutical Sciences, Nagasaki University

• SHIMADA Hideaki

  Faculty of Education, Kumamoto University

• Ohta Kazuko

  Faculty Of Pharmaceutical Sciences Nagasaki University

• FUJITA Kahee

  Faculty of Pharmaceutical Sciences, Nagasaki University

• IKEGAMI Yoshihiro

  Faculty of Pharmaceutical Sciences, Nagasaki University

• NOGAMI Yasuyoshi

  Daiichi College of Pharmaceutical Sciences

• KOGA Toshitaka

  Daiichi College of Pharmaceutical Sciences

• 古賀 隆樹

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Shimada Hideaki

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Shimada Hideaki

  Faculty Of Education Kumamoto University

• Fujita Kahee

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Koga T

  Daiichi College Of Pharmaceutical Sciences

• Fujita Ken-ichi

  Department Of Biology And Geosciences Graduate School Of Science Osaka City University

• Ikeda Y

  Department Of Drug Metabolism And Disposition Meiji Pharmaceutical University

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