Novel Antiasthmatic Agents with Dual Activities of Thromboxane A_2 Synthetase Inhibition and Bronchodilation. V.Thienopyridazinone Derivatives

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概要

• 論文の詳細を見る

• Synthesis and pharmacological evaluation of novel thienopyridazinones and related compounds are described.A thiophene ring was found to be able to replace the benzene ring of a phthalazinone without loss of biological activities. This observation supports our hypothesis that the benzene ring plays an important role in both thromboxane A_2 (TXA_2) synthetase-inhibitory and bronchodilatory activities. Further, it was shown that the carbonyl moiety of a phthalazinone is not necessary for these activities.

• 公益社団法人日本薬学会の論文
• 1995-02-15

著者

• 大井 信広

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 古賀 隆樹

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Yamaguchi M

  Gifu Pharmaceutical University

• 黒木 俊夫

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• Koga T

  Daiichi College Of Pharmaceutical Sciences

• 丸山 典昭

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 亀井 研志

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 山口 雅久

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 秋間 通立

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 濱名 政和

  Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd.,

• 山口 雅久

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 濱名 政和

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 秋間 通立

  Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.

• 丸山 典昭

  Fuji-Gotemba Laboratories, Chugai Pharmaceutical, Co., Ltd.,

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