Oxidative Stress-Dependent Inhibition of Yeast Cell Growth by Farnesylamine and Its Possible Relation to Amine Oxidase in the Mitochondrial Fraction(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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概要

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• Among various analogs of the isoprenoid farnesol (FOH), farnesylamine (FNH_2) inhibited the growth of the budding yeast Saccharomyces cerevisiae by accelerating cellular reactive oxygen species (ROS) generation. Unlike the case with FOH, however, FNH_2 did not cause mitochondrial transmembrane potential (mtΔψ) hyperpolarization so that FNH_2-treated cells were not protected against ROS production by inhibiting the proton pumping function of mitochondrial F_OF_1-ATPase. FNH_2 promoted ROS generation even in cells of a respiration-deficient mutant, indicating a yeast metabolic pathway other than mitochondrial electron transport as the origin of ROS. FNH_2 oxidase activity was detected in the yeast mitochondrial fraction, which produces hydrogen peroxide (H_2O_2) in the reaction with either FNH_2 or geranylgeranylamine (GGNH_2), in addition to polyamine oxidase activity specific for spermine. GGNH_2 also exhibited the growth inhibitory effect with the accompanying induction of ROS generation, while such an activity was not detected with any of the polyamines tested or geranylamine. FNH_2 oxidase, which was sensitive to a typical copper-chelating agent, diethyldithiocarbamic acid (DDC), could be solubilized with Triton X-100, and detected as a single band upon activity staining with FNH_2 but not with spermine in polyacrylamide gel electrophoresis. FNH_2-treated cells were partly protected against ROS production by the additional supplementation of DDC in the medium. Our results suggest the involvement of H_2O_2 production due to direct oxidation of FNH_2 by copper amine oxidase in oxidative stress-dependent inhibition of yeast cell growth.

• 社団法人日本生物工学会の論文
• 2004-12-25

著者

• Tano Tatsuo

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• 田中 孝明

  新潟大・工・機能材料

• Fukamachi K

  Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences

• Tanaka T

  Graduate School Of Science Osaka City University

• Taniguchi M

  Graduate School Of Science Osaka City University

• TANIGUCHI Makoto

  Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital

• Fujita K

  Graduate School Of Science Osaka City University

• Fujita K

  Tohoku Univ. Sendai Jpn

• Tanaka Toshio

  Department Of Respiratory Medicine Allergy And Rheumatic Disease Osaka University Graduate School Of

• FUJITA Ken-ichi

  Department of Medical Oncology, Comprehensive Cancer Center, Saitama Medical University

• Taniguchi Makoto

  Graduate School of Science, Osaka City University

• HIRASAWA Eiji

  Department of Biology, Faculty of Science, Osaka City University

• USUKI Yoshinosuke

  Department of Material Science, Graduate School of Science, Osaka City University

• HIJIOKA HARUKA

  Department of Bio- and Geoscience, Graduate School of Science, Osaka City University

• Taniguchi Makoto

  Graduate School Of Science Osaka City University

• Fujita Ken-ichi

  Graduate School Of Science Osaka City University

• Hirasawa E

  Graduate School Of Science Osaka City University

• Hirasawa Eiji

  Department Of Agricultural Chemistry Kyoto University

• Hijioka Haruka

  Department Of Bio- And Geoscience Graduate School Of Science Osaka City University

• Usuki Yoshinosuke

  Graduate School Of Science Osaka City University

• Fujita Ken-ichi

  Department Of Biology And Geosciences Graduate School Of Science Osaka City University

• Usuki Yoshinosuke

  Department Of Chemistry College Of Arts And Sciences The University Of Tokyo

• Tanaka Toshio

  Department Of Cardiology Matsusaka Central General Hospital

• Taniguchi Makoto

  Deprtment Of Bio- And Geoscience Graduate School Of Science Osaka City University

• Taniguchi M

  Taiyo Kagaku Co. Ltd. Mie Jpn

• Taniguchi Makoto

  Department Of Biology Faculty Of Science Osaka City University

• Taniguchi Makoto

  Department Of Bio- And Geoscience Gradaute School Of Science Osaka City University

• Tanaka Toshio

  Department Of Applied Physics Faculty Of Engineering Tokyo University

• Fujita K

  Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences

• Fukamachi Katsumi

  Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences

• Usuki Yoshinosuke

  Department Of Molecular Materials Science Graduate School Of Science Osaka City University

• Tanaka Toshio

  Department of Applied Chemistry, Faculty of Engineering, Osaka Univeristy

• TANIGUCHI Makoto

  Department Medical Research Institute Kanazawa Medical University

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