Saponin and Sapogenol. XIV. Antifugal Glycosides from the Sea Cucumber Stichopus japonicus SELENKA. (1). Structure of Stichopogenin A_4,the Genuine Aglycone of Holotoxin A

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概要

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• Three antifugal glycosides named holotoxin A (major), B, and C have been isolated from the Far Eastern sea cucumber Stichopus japonicus SELENKA. Aqueous acid hydrolysis of holotoxin A furnished genin-1 (a mixture of stichopogenin A_2 (3b) and the isomer) and stichopogenin A_4 (=genin-2) (3a) in addition to xylose, quinovose, 3-O-methyl-glucose, and glucose, while mild methanolic acid hydrolysis of holotoxin A gave 3a and another new aglycone named 25-O-methyl-stichopogenin A_4 (=genin-3) (3c). On the basis of chemical and physicochemical evidence, the structure of stichopogenin A_4,the genuine aglycone of holotoxin A, has been elucidated to be expressed as 3a rather than previously proposed 2,and the structure of 25-O-methyl-stichopogenin A_4 as 3c.

• 公益社団法人日本薬学会の論文
• 1976-02-25

著者

• 吉岡 一郎

  Faculty Of Pharmaceutical Sciences Osaka University

• 栗山 馨

  Shionogi Research Laboratories Shionogi And Co.

• 菅原 民雄

  Faculty Of Pharmaceutical Sciences Osaka University:(present Address)shionogi Research Laboratory Sh

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