Saponin and Sapogenol. XV. Antifungal Glycosides from the Sea Cucumber Stichopus japonicus SELENKA. (2). Structures of Holotoxin A and Holotoxin B

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概要

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• The structure of holotoxin A, the major antifungal glycoside isolated from the Far Eastern sea cucumber Stichopus japonicus SELENKA, has been elucidated as 4 on the bases of chemical and physicochemical evidence and enzymatic hydrolysis. Holotoxin B (14), a minor antifungal glycoside of the same origin, has been suggested to be the glucoside of holotoxin A (4) on the similar basis. Holotoxin C, another minor glycoside, has been suggested to be the similar type of glycoside as holotoxin A and B. Holotoxin A and B are distinctive by the possession of two α-linkages of D-xylose and D-quinovose in the oligosaccharide portion. Finally, comparison of the anti-microbial activity of holotoxins with the various kinds of saponins isolated from the plant materials has been presented.

• 公益社団法人日本薬学会の論文
• 1976-02-25

著者

• 吉岡 一郎

  Faculty Of Pharmaceutical Sciences Osaka University

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 菅原 民雄

  Faculty Of Pharmaceutical Sciences Osaka University:(present Address)shionogi Research Laboratory Sh

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