Saponin and Sapogenol. XXV. Steroidal Saponins from the Starfish Acanthaster planci L. (Crown of Thorns). (1). Structures of Two Genuine Sapogenols, Thornasterol A and Thornasterol B, and Their Sulfates
スポンサーリンク
概要
- 論文の詳細を見る
The saponin mixture has been isolated from the whole body of starfish Acanthaster planci L. (crown of thorns). By use of the glycosidase mixture from the large marine gastropod Charonia lampas, which is known as a natural enemy of A. planci, two genuine sapogenols named thornasterol A (8) (major) and thornasterol B (9) (minor) have been isolated as their diacetates from the saponin mixture. On the basis of chemical reactions and physicochemical evidence, the structures of diacetyl-thornasterol A and diacetyl-thornasterol B have been elucidated to be 3β, 6α-diacetoxy-5α-cholest-9 (11)-en-20-ol-23-one (8a) and 24ε-methyl-3β, 6α-diacetoxy-5α-cholest-9 (11)-en-20-ol-23-one (9a), respectively. Furthermore, the sulfate group contained in the parent saponins of thornasterol A (8) and B (9) has been shown to attach to 3β-OH of the respective sapogenols. It has been also suggested that the pregnane-type sapogenol (1), which has been hitherto isolated not only from A. planci but also from many other species of Asteroidea, may be an artifact sapogenol.
- 公益社団法人日本薬学会の論文
- 1978-06-25
著者
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小林 資正
Faculty of Pharmaceutical Sciences, Osaka University
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Kobayashi M
Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North
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Kobayashi M
Faculty Of Pharmaceutical Sciences Osaka University
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菅原 民雄
Faculty Of Pharmaceutical Sciences Osaka University:(present Address)shionogi Research Laboratory Sh
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