Characterization of Hyperinsulinemic Recombinant Inbred (RI) Strains (SMXA-5 and SMXA-9) Derived from Normoinsulinemic SM/J and A/J Mice
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概要
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We discovered two mouse strains (SMXA-5 and SMXA-9) with hyperinsulinemia among the substrains and progenitor strains (SM/J and A/J) of the SMXA recombinant inbred (RI) strains, and characterized the two strains at 20 weeks of age. SMXA-5 (mean ± S.E.M: 9.6 ± 1.7 ng/ml) and SMXA-9 (7.7 ± 1.3 ng/ml) males had higher serum immunoreactive insulin levels than SM/J (1.4 ± 0.3 ng/ml) and A/J (1.1 ± 0.1 ng/ml) males in the nonfasting condition. The hypoglycemic response to insulin at 30 min after injection was significantly less in SMXA-5 males than in SM/J mice. Glucose tolerance test revealed that the incidence of impaired glucose tolerant males was 58% (11/19) in SMXA-5 and 42% (10/24) in SMXA-9 strains, but none in SM/J and A/J strains. SMXA-5 (209 ± 29 mg/dl) and SMXA-9 (235 ± 31 mg/dl) had higher serum triglyceride levels than SM/J (126 ± 14 mg/dl) and A/J (89 ± 5 mg/dl) males in the nonfasting condition. Histologic examination revealed enlarged islets in the pancreas of hyperinsulinemic SMXA-5 male mice. Moreover, SMXA-5 and SMXA-9 mice exhibited mild obesity. SMXA-5 and SMXA-9 males were therefore characterized by hyperinsulinemia, impaired glucose tolerance, hypertriglyceridemia and mild obesity which resembled some of the phenotypes of human Syndrome X, although both progenitor strains were normal so far as we examined. Since the RI strains are a powerful tool to facilitate polygenic-trait analysis, SMXA-5 and SMXA-9 mice will be useful materials to investigate the genetic basis of complex diseases, and are possible new metabolic models in relation to hyperinsulinemia.
- 社団法人 日本実験動物学会の論文
著者
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NAMIKAWA Takao
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
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TANAKA Shin
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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TANAKA Shin
National Institute of Longevity Sciences, National Chubu Hospital
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NISHIMURA Masahiko
Institute for Laboratory Animal Research, Nagoya University School of Medicine
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HORIO Fumihiko
Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University
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Ohno T
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Ohno Tamio
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Ohno Tamio
Department Of Parasitology Hamamatsu University School Of Medicine
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Tanaka Shin
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg)
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Horio F
Nagoya Univ. Nagoya Jpn
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Horio Fumihiko
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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Namikawa T
Nagoya Univ. Nagoya Jpn
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Namikawa Takao
名古屋大学 生命農学研究科動物遺伝制御学
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Namikawa Takao
Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri
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Namikawa Takao
Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology
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ANUNCIADO Rea
Department of Basic Veterinary Sciences, College of Veterinary Medicine, University of the Philippin
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Nishimura M
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Nishimura Masahiko
Institute For Experimental Animals Hamamatsu University School Of Medicine
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Tanaka Shin
鹿児島大学 農学部獣医学科解剖学分野
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Nishimura Masahiko
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Anunciado Rea
Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University.
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Tanaka Shin
National Institute For Longevity Scienes
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